Evaluation of an animal model for the quantitative analysis of articular degeneration
Rodríguez Altónaga JA 1, Moya Angeler J 2, Forriol F 2
1 Departamento de Cirugía. Facultad de Veterinaria. Universidad de León. León, España.
2 Facultad de Medicina, Universidad San Pablo CEU, Campus Montepríncipe, Boadilla del Monte, Madrid, España.
To evaluate joint degeneration on four surgically induced models of Osteoarthritis in the Ovine´s stifle in order to establish a model of early joint degeneration using different magnetic resonance imaging semi quantitative scales.
Material and methods
Twenty, 3-year old merino female sheep were randomly assigned to one of four open procedures: Group 1 anterior cruciate ligament transection, Group 2 total medial meniscectomy, Group 3 anterior cruciate ligament transection combined with total medial meniscectomy and Group 4 mid-body transection of the medial meniscus. All sheep were euthanized at 8 weeks post-surgery, when the magnetic resonance imagings were performed. The assessment of joint degeneration was performed using the WORMS, BLOCK and MOAKs scales.
Group 3 (anterior cruciate ligament transection combined with total medial meniscectomy) obtained the highest values of joint degeneration followed by Group 4 (mid-body transection of the medial meniscus). Groups 1 (anterior cruciate ligament transaction) and 2 (total medial meniscectomy) showed similar values.
Induced anterior cruciate ligament transection combined with total medial meniscectomy in the Ovine´s stifle induced a higher degree of joint degeneration than the rest of models described in the literature.
Osteoarthritis, magnetic resonance, OARSI, BLOCK, WORMS.
Correspondencia:JA Rodríguez Altónaga
Dpto. Cirugía-Facultad de Veterinaria, Universidad León, León, España.